S: (n) decimation (destroying or killing a large part of the population (literally every tenth person as chosen by lot))
S: (n) self-destruction (the act of destroying yourself) "his insistence was pure self-destruction"
S: (n) neutralization, neutralisation ((euphemism) the removal of a threat by killing or destroying it (especially in a covert operation or military operation))
S: (n) sabotage (a deliberate act of destruction or disruption in which equipment is damaged)