Noun

• S: (n) annoyance, chafe, vexation (anger produced by some annoying irritation)
• S: (n) irritation, annoyance, vexation, botheration (the psychological state of being irritated or annoyed)
• S: (n) concern, worry, headache, vexation (something or someone that causes anxiety; a source of unhappiness) "New York traffic is a constant concern"; "it's a major worry"
• S: (n) annoyance, annoying, irritation, vexation (the act of troubling or annoying someone)